Um dos mais apelativos legados da tradição filosófica ocidental, o argumento ontológico, é aqui retomado com base na sua versão inaugural, a de Proslogion 2-3, de Anselmo de Cantuária. Este artigo representa um momento culminante de um processo de reflexão pessoal e de revisão continuada da compreensão do argumento anselmiano por parte da autora. Há, por isso, aqui um testemunho de auto-crítica e a definição clara de uma linha interpretativa, que não evita recusar orientações tradicionalmente dominantes na interpretação do argumento (...) de Anselmo. Uma dessas orientações é a admissão de que a noção anselmiana de Deus, em Proslogion 2-3, é um conceito a priori. Ao contrário, defende este estudo, através da análise do processo de construção dessa noção, que a mesma não pode ser classificada, nos termos da filosofia de Kant, senão como uma noção a posteriori. Outra dessas orientações é a concessão do primado da essência sobre a existência na filosofia do argumento anselmiano. Pelo contrário, este estudo defende o primado da existência na elaboração do argumento anselmiano do Proslogion, o que se prova através da consideração quer do sentido da distinção entre essência e existência quer do teor metafísico dos princípios que operam no argumento. /// One of the most appealing legacies of the western philosophical tradition, the ontological argument, is considered in this paper, based on its inaugural version, the one of Anselm of Canterbury's Proslogion 2-3. The paper represents the apex of a process of personal reflection and continual review of the understanding of the Anselmian argument on the part of its author. Therefore, there is here a testimony of self-critique and the clear definition of an interpretative line, which does not avoid the refusal of traditionally dominant orientations in the interpretation of Anselm s argument. One of these orientations admits that the Anselmian concept of God, in Proslogion 2-3, is an a priori concept. This study, on the contrary, claims, through the analysis of the construction process of this concept, that it cannot be classified, according to Kant's philosophy, but as an a posteriori concept. Another of the traditional orientations is the concession of the primacy of the essence over existence in the philosophy of the Anselmian argument. On the contrary, through the consideration of the meaning of the distinction between essence and existence, as well as the metaphysical tenor of the principles operating in the argument, the author claims the primacy of existence in the elaboration of the Anselmian argument in the Proslogion. (shrink)

This study, the third in a series of three, draws on a broader Norwegian research project exploring the phenomenon of support for young persons with mental health issues. The aim was to explore and explicate the sense of “nourishing communion”, as a somewhat neglected aspect of support. Fourteen Norwegian young adults, aged 18-25, were interviewed about their experiences of support. Data was analyzed using van Manen’s hermeneutic-phenomenological approach to open up possible meanings of how nourishing communion is concretely lived. Analysis (...) was supplemented by in-depth reflexive dialogues between the first and second author, which fostered a nourishing communion akin to the processes and dimensions of our phenomenon of interest. Findings highlight five intertwined existential themes: a) trusting the other to hold vulnerability safely; b) flourishing in mutual participation; c) acceptance in a felt togetherness; d) feeling found and received; and e) feeling an attuned resonance. The notion of “nourishing communion” as a significant but neglected element of support challenges current practice, suggesting the need for a different approach to collaboration with young persons and their networks. From the perspectives both of individual professional engagement and of policy making, there is a need for further exploration of how young persons might be supported to create and maintain a broader range of nourishing relationships. (shrink)

To a field of study not intensively cultivated by Marxists, Wikse contributes a criticism of what he calls "idiocy," the tendency to regard the self as private property. Whereas earlier writers like L. Sève or A. Schaff focused principally upon psychological and philosophical theories of the person, Wikse directs attention rather to experience, his own and that of others, mainly as this is reflected in language.

«Jo només escric», diu l'autor, «quan les sensacions o idees se'm fan dimonis íntims que intento foragitar amb la literatura. Però no resulta fàcil sentir ni pensar amb naturalitat i seguretat, superar els propis vertígens i censures, deixar avançar la ment amb la confi ança que trobarà el que busca, la mateixa confiança amb què el rei s'asseu sense mirar enrere, segur que trobarà la cadira que algú li haurà acostat.Un entorn raonablement sensual i fins i tot una relativa gimnàstica (...) sexual ajuden sens dubte l'esperit: el que aquest no admet és cap lligam sentimental. Al cervell no li roba energia el moblament sensual o l'erotisme profilàctic, és a dir, tot allò que apaivaga un cos que ha de funcionar alhora com la seva font d'energia i el seu instrument. El pensament ens permet, doncs, el que ens estabilitza però no el que ens mobilitza; tolera el que ens gratifica però no el que ens sedueix. Més que en la repressió, el pensament i la cultura es basen en la fredor, s'aixequen sobre l'egoisme i es mantenen a força de narcisisme. Ens perdonen tal volta els plaers, però mai els amors». (shrink)

Alterations to cognitive function are often reported with depression and anxiety symptoms, yet few studies have examined the same associations with mental well-being. This study examined the association between mental well-being, depression and anxiety symptoms and cognitive function in 1502 healthy adult monozygotic and dizygotic twins, and the shared/unique contribution of genetic and environmental variance. Using linear mixed models, mental well-being was positively associated with sustained attention, inhibition, cognitive flexibility, motor coordination and working memory, whereas depression and anxiety symptoms were (...) associated with poorer sustained attention, inhibition, cognitive flexibility and executive function. Bivariate twin modelling showed well-being shared a small environmental correlation with motor coordination and a small genetic correlation with working memory. Trivariate twin modelling showed well-being shared a small genetic correlation with inhibition, whereas depression and anxiety symptoms shared a small environmental correlation with inhibition. The remaining variance was mostly driven by unique G and/or E variance. Overall, well-being and depression and anxiety symptoms show both independent and shared relationships with cognitive functions but this is largely attributable to unique G or E variance and small shared G/E variance between pairs of variables. (shrink)

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

Research demonstrates a relation between disgust and anxiety-related pathology; however, research has yet to reveal mechanisms by which disgust may contribute to anxiety. The current experiment examined attentional bias characteristics as one route by which disgust influences anxiety. Eighty undergraduate participants completed a rapid serial visual presentation attention task using fear, disgust, or neutral target stimuli. Task-relevance of the target's presentation was also manipulated. Results revealed that task-relevant disgust targets impaired attention among all participants, but task-irrelevant disgust targets impaired attention (...) only in high disgust prone individuals. Difficulty in disengagement characterised both disgust and fear attentional biases, but the difficulty in disengagement was greater for disgust compared to fear attentional biases. High disgust prone individuals displayed exaggerated difficulty in disengaging attention from disgust targets compared to low disgust prone individuals. The results suggest that disgust attentional biases differ from fear attentional biases. The characteristics of disgust attentional biases are discussed as possible mechanisms by which disgust functions in certain anxiety disorders. (shrink)

The evolutionary implications of environmental change due to organismic action remain a controversial issue, after a decades—long debate on the subject. Much of this debate has been conducted in qualitative fashion, despite the availability of mathematical models for organism–environment interactions, and for gene frequencies when allele fitness can be related to exploitation of a particular environmental resource. In this article we focus on representative models dealing with niche construction, ecosystem engineering, the Gaia Hypothesis and community interactions of Lotka–Volterra type, and (...) show that their quantitative character helps bring into sharper focus the similarities and differences among their respective theoretical contexts. (shrink)

Mammalian mitochondrial DNA (mtDNA) replication and repair have been studied intensively for the last 50 years. Although recently advances in elucidating the molecular mechanisms of mtDNA maintenance and the proteins involved in these have been made, there are disturbing gaps between the existing theoretical models and experimental observations. Conflicting data and hypotheses exist about the role of RNA and ribonucleotides in mtDNA replication, but also about the priming of replication and the formation of pathological rearrangements. In the presented review, we (...) have attempted to match these loose ends and draft consensus where it can be found, while identifying outstanding issues for future research. (shrink)

High-spin states in the odd-odd N = Z nucleus Co-54 have been investigated by the fusion-evaporation reaction Si-28(S-32,1 alpha 1p1n)Co-54. Gamma-ray information gathered with the Ge detector array Gammasphere was correlated with evaporated particles detected in the charged particle detector system Microball and a 1 pi neutron detector array. A significantly extended excitation scheme of Co-54 is presented, which includes a candidate for the isospin T = 1, 6(+) state of the 1f(7/2)(-2) multiplet. The results are compared to large-scale shell-model (...) calculations in the fp shell. Effective interactions with and without isospin-breaking terms have been used to probe isospin symmetry and isospin mixing. A quest for deformed high-spin rotational cascades proved negative. This feature is discussed by means of cranking calculations. (shrink)

Purpose/methods: This study investigated the relationship between ethics education and training, and the use and usefulness of ethics resources, confidence in moral decisions, and moral action/activism through a survey of practicing nurses and social workers from four United States (US) census regions. Findings: The sample (n = 1215) was primarily Caucasian (83%), female (85%), well educated (57% with a master's degree). no ethics education at all was reported by 14% of study participants (8% of social workers had no ethics education, (...) versus 23% of nurses), and only 57% of participants had ethics education in their professional educational program. Those with both professional ethics education and in-service or continuing education were more confident in their moral judgments and more likely to use ethics resources and to take moral action. Social workers had more overall education, more ethics education, and higher confidence and moral action scores, and were more likely to use ethics resources than nurses. Conclusion: Ethics education has a significant positive influence on moral confidence, moral action, and use of ethics resources by nurses and social workers. (shrink)

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

In many research studies, tumor biopsies are an unavoidable requirement for achieving key scientific aims. Yet some commentators view mandatory research biopsies as coercive and suggest they should be optional, or at least optional until further data are obtained regarding their scientific usefulness. Further complicating the ethical picture is the fact that some research biopsies offer a potential for clinical benefit to trial participants. We interviewed and surveyed a convenience sample of participants in phase I clinical trials at a single (...) institution. Our primary aim was to describe phase I participants’ understanding of whether a research biopsy offered them the prospect of medical benefit. We also endeavored to describe participants’ views about biopsies—specifically, the benefits of biopsies, if any, and whether biopsies were acceptable, risky, or discouraged trial participation. Finally, we collected data on demographics and attitudes to see if any strong correlations with misunderstanding, acceptability, or riskiness existed. Overall, the respondents tended to view research biopsies as acceptable, though they did not succeed in identifying the lack of benefit of a research biopsy. These findings call for renewed efforts in consent conversations and documents to carefully describe the benefits, or lack thereof, of research biopsies. (shrink)

In a recent article1 mention was made of a MS. from which Goetz printed selections in Vol. V. of the . This MS. was not used by Goetz. On fol. 81 appears the following entry: ‘Moechus est adulter alterius t[h]orum furtim polluens; inde a m echo dicitur m[o]echanica ars, ingeniosa atque subtilissima et p ene quomodo facta uel administrata sit inuisibilis in tantum, ut etiam uisum conspicientium quodam modo furetur, dum non facile penetratur eius ingeniositas quali ingenio artis candelabrum illud (...) Theodosianum factum legitur.’. (shrink)

In this paper we describe an experimental test of the validity of the Pauli Exclusion Principle (for electrons) which is based on a straightforward idea put forward a few years ago by Ramberg and Snow (Phys. Lett. B 238:438, 1990). We perform a very accurate search of X-rays from the Pauli-forbidden atomic transitions of electrons in the already filled 1S shells of copper atoms. Although the experiment has a very simple structure, it poses deep conceptual and interpretational problems. Here we (...) describe the experimental method and recent experimental results, which we interpret in the framework of quon theory. We also present future plans to upgrade the experimental apparatus using Silicon Drift Detectors. (shrink)

C. Prien, Rh. Mus. 6, 192f.: ‘…so habe ich vor Jahren schon vermuthet [but lot published, apparently] ρκιóν γ' αδουμνους mit Vergleichung der Stellen V. 650 = 680] ρκον αδεσθε und 680 [ = 710] αδουμνους τòν ρκον, ohne sie für evident usgeben zu wollen.’.

I Want to comment on five passages where I have provoked disagreement by a previous discussion. In the first three, my discussion was in Philologus cx , 152–4, and my critic is Bruno Gentili in Quaderni Urbinati iv , 177–81. I was not the first to make an emendation in any of the three places, so that in defending the transmitted text Gentili is actually not only criticizing me but others such as Hermann, Naeke, O. Müller, Schoemann, Hunt, Murray, and (...) Page. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

In the article by A. Kolodny and L. Fylypovych, dedicated to Ivan Ogienko, the Ogienko's vision of the features of the Orthodox Churches locality, in particular the specifics of their manifestation in the Ukrainian Orthodox Church, is presented. The main features of Ukrainian Orthodoxy are revealed.

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

‘The reading of the MSS, and not the Renaissance correction e, is certainly what L. wrote.’ So Kenney in his edition of Lucretius 3.1 I believe that he is right, but that the case for o rests on different grounds from those which he adduces. Kenney quotes D.A. West 's statement that e is ‘not worthy of the precise and vivid imagination of this poet’, and himself finds it anaemic by contrast with the sonorous o.2 These are subjective judgements. One (...) can only reply by expressing disagreement and pointing out that e has seemed unexceptionable to the numerous editors who have printed it and have preferred it to o. (shrink)